Confirmed
Brian Heder's smuggling operation
The long running drug smuggling business in the Keys that Jason and Cal work for.

Notes
Brian Heder has been running drugs through the Leonida Keys since the 1980s. Jason and Cal both work for him, which is how the story finds Jason at the start.
Rockstar has not given the operation a name.
Sources
Grand Theft Auto VI official site: people and places (opens in a new tab)
Brian, Jason, and Cal's bios describe the operation.
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